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Conclusions: Fetal factor V Leiden mutation and prothrombin gene mutation may influence the course of severe preeclampsia, IUGR and placental abruption.
The location of the mutation may influence the clinical course of the disease 5, 10.
Thus, alterations of this complex by E50K mutation may influence the entire cellular function, leading to glaucomatous-like pathology.
Numerous studies have investigated with conflicting results whether functional loss of VHL or the type of VHL mutation may influence prognosis in ccRCCs (reviewed in 39).
Located on the surface of the PB2 cap-binding domain (9 ), the Pro453Ser mutation may influence polymerase function and virus replication.
Alternatively, a mutation may influence pathology via an injurious gain-of-function unrelated to the canonical activity, for example by acquisition of a new interaction with protein or RNA (Fig 2, mechanism i).
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It was suggested that these mutations may influence viral replication and alter the HBV-protein expression [ 4- 6].
The results suggest that TP53 mutations may influence IR-induced cell cycle delay (Table 5).
Host immune response and HBV gene mutations may influence the development and severity of liver fibrosis [ 4].
These findings suggest that AP2σ2 mutations may influence Ca2+o homeostasis through effects on cell membrane proteins other than the CaSR.
Nevertheless, height mutations may influence other traits, causing antagonistic pleiotropy and resulting in the maintenance of such alleles.
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