Sentence examples for mutation may induce from inspiring English sources

Indeed, since W317 seals together two spatially neighboring loops, the W317K mutation may induce long-range conformational changes on the SH3 domain.

The H1047R (exon 20) mutation may induce an allosteric change that mimics Ras-GTP binding, making this mutant independent of interaction with Ras-GTP [ 5].

The C/EBPβΔuORF/BL6 mutation may induce a similar metabolic roundabout of enhanced WAT function and fat turnover coupled to increased fatty acid oxidation.

For instance, the difference in the physical parameter encoding the volume of an amino acid can suggest if the mutation may induce strain in the protein structure due to the large size of the introduced residue.

Based on a careful observation of the structure of the C-domain of ACE (12), we predict that the R828H mutation may induce multiple new interactions with residues of the 840 loop region which could contribute to the misfolding of the protein by the disruption of the helical (α8) structure and the salt bridge (R829 E1188) stabilizing the C-terminal loop (Fig.  7B, 1 and 2).

The BCRP mutations may induce conformational changes as manifested by the altered uptake rates of Mitoxantrone by BCRP in the presence of other competitive binding substrates that have a varying degree of affinities toward BCRP efflux.

Functional studies have demonstrated that CLDN16 mutations may induce partial or complete loss of protein function [ 12, 15].

Although these GRN levels fall outside the range of the typical loss-of-function mutations, these mutations may induce a partial loss-of-function.

An alternative hypothesis is that PIK3CA mutations may induce senescence, resulting in a less aggressive phenotype compared with activation of other pathways.

However, several studies have shown that loop 5 mutations may induce resistance problems such as those demonstrated in colorectal cancer cells [ 22].

These mutations may induce stress on the endoplasmic reticulum leading to defective intracellular protein transport between the golgi and the endoplasmic reticulum; such defects have been linked to autoimmune and lung-disease.