Sentence examples for mutation may indicate from inspiring English sources
Therefore, the fact that ERBB2 amplification is rare in tumors with BRCA1 mutation may indicate that ERBB2 amplification is dependent on mutagenic homology-directed repair.
The relatively small (3 °C) decreases in melting temperature by the quite drastic Asp56 deletion mutation and the R232A/P233G/L234R/D235P four-fold mutation may indicate that these residues are not in a so-called weak spot of the protein that is more sensitive for unfolding (Eijsink et al. 2004), although the higher B-factors had suggested it to be.
The greater potentiation by the S155W mutation may indicate that a larger than normal side chain protruding into an anesthetic binding site accentuates an effect resulting from anesthetic binding, especially with the tryptophan side chain being significantly larger than a single halothane molecule.
Pathogenic mtDNA mutations may indicate for their functional contribution in progression of the tumors.
In the near future, identification of additional mtDNA mutations may indicate further candidate genes for hypertension.
Overexpression of β-catenin and KRAS mutations may indicate that ACF constitute a premalignant stage [ 16].
These frameshift mutations may indicate a loss of function in this gene copy.
Third, the high frequency of trait-increasing mutations may indicate the trait is not actually a fitness component.
Although no tumor was detected in our cohort of women, these mutations may indicate mtgenome instability, perhaps suggesting an elevated risk for breast cancer in these 4 women.
This hypothesis is supported by a high rate of somatic G to A transitions in CpG dinucleotides of the TP53 gene in esophageal tumor samples from geographical areas in which drinking hot beverages is considered an important risk factor for EC [ 59- 62]; these mutations may indicate increased nitric oxide synthase activity in tumors [ 63].
This 100% mutation frequency may indicate that this nucleotide transition is a fixed mutation in MTB and one that has essentially benefited the strain's survival and/or host infectivity.
