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As described in the methods, we created a randomized mutation matrix then added an RME module consisting of two to five genes.
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We remove these five genes (RB1, CDKN2A, CDKN2B, CDK4, and TP53) from the mutation matrix and then apply SAGA to discover the others genes.
A mutation matrix A is then obtained by reducing the size of A0 by combining genes that are mutated in the same samples into larger 'metagenes'metagenes
These two forms of data were then merged into a two-dimensional mutation matrix.
(a) The mutation matrix.
The first is the mutation matrix.
The mutation matrix is available in the protein_matrix.txt format.
The mutation matrix is ideal for an investigator who wants access to the raw data.
Finally UMS was applied to these proteins to produce the mutation matrix, standard and clustered heat maps, and the patterned structure.
The matrix, then, is the site of creativity.
The mutation matrix (M-matrix) represents the effects of new mutations on trait variances and covariances.
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