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In genetic terms, it would seem that Vangl2 Lp and Celsr1 Crsh are epistatic to Scrib Crc, because the addition of a Scrib Crc mutation makes little difference to the phenotype of the Vangl2 Lp /+; Celsr1 Crsh /+ double mutant.
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This imputation makes little difference.
For the well- known driver genes EGFR, CDKN2A, KRAS, STK11, TP53 which already have computed P-values of zero due to frequent mutations, the effect of scoring makes little difference.
In an attempt to replicate their repeatability analysis, I was forced to assume that the use of different probes and different enzymes makes little difference to the mutation rate estimate, but this assumption is probably false.
That makes little sense.
This makes little sense, substantively.
His body makes little twitches.
Taxing income makes little sense.
This makes little practical difference.
The figure makes little sense otherwise.
Reassuringly, introduction of this mutation made very little difference to transmission efficiency and pathogenesis and in fact has been reported to attenuate transmission [ 15].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com