Sentence examples for mutation maintenance from inspiring English sources

The direct medical costs considered in the model were: the detection of EGFR mutation, maintenance and 2nd-line chemotherapy (including prescription, preparation, and administration), concomitant medication during therapy, managing treatment-related SAEs, routine follow-up and laboratory tests.

It would be expected that this increased concentration of enzyme originates from higher stability, which could offset lower activity resulting in better mutation maintenance in the absence of insecticide.

In such a scenario many of the genes found to vary between genotypes are likely to reflect differences associated not only with the effects of inbreeding depression and founder effects, but also in the accumulation of mutations during maintenance.

In sum, it is likely that tissue context and differences in the stem cell biology across different tissues and species influence the requirement for stem cell quiescence for suppression of DNA damage, genetic mutations, and maintenance of stem cell function.

We posited that the SPOP mutation impacts genome maintenance and prioritized SPOP for functional studies.

Our observation of the delayed aging of the gastrocnemius is consistent with a potentially global beneficial effect of this mutation on the maintenance and renewal of multiple tissues.

These anthropogenic or climatic factors may influence the maintenance, mutation or loss of negative regulators of virulence, by shifting the costs and benefits of pathogenesis, potentially driving the rise of hypervirulence.

These data demonstrated the causal relationship between the TERT promoter mutations and telomere maintenance and showed that the TERT promoter mutations can up-regulate TERT levels sufficiently to suppress telomere erosion without additional tumor-selected changes.

To examine whether the mcl1-101 and swi7-H4 mutaffect affecthehe maintenance of the chromatin structure at the central core region, each mutation was introduced into cnt1:ura4+ strain in which ura4+ marker gene is inserted into cnt1 [19].

Mutations that reduce CG gene body methylation (e.g., mutations in the maintenance DNA methyltransferase) affect CG methylation in all genomic contexts.

Overall speed of mtDNA replication synthesis, turnover, mtDNA organization and the existence of backup mechanisms, such as active recombination, could be limiting for many disease mutations of mtDNA maintenance proteins that do not show any phenotype in cultured cells or in vitro [19], [33].