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Reassuringly, introduction of this mutation made very little difference to transmission efficiency and pathogenesis and in fact has been reported to attenuate transmission [ 15].
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Due to the rapid evolution of bacterial populations and genomes, the footprint left by a recombination event can quickly be "eroded" by mutation and drift, making very difficult to detect ancient recombination events (discussed earlier).
This mutation made melanoma cells vulnerable to Zelboraf.
A conservative algorithm with high specificity may make very few incorrect predictions, but may miss many legitimate somatic mutations because of its low sensitivity.
These mutations make a very stable hairpin conformation with −40.6 kcal/mol predicted free energy at 37 °C, making the equilibrium constant for folding to the hairpin predicted to be 8 × 10-fold more favorable than to the multibranch conformation (see captions to Figures 3 and 5).
Since 16S rRNA makes very specific contacts with many different ribosomal proteins and with other parts of itself, the pace at which spontaneous random mutation can change the sequence of the bases in the rRNA is slow.
He makes very bad pictures.
Make very little noise.
"Mutation" makes her think of swamp monsters, nuclear accidents, hands growing out of heads.
The variability in clinical presentation and underlying causative mutations make the diagnosis very challenging, involving extensive clinical and specialized laboratory evaluation [ 3].
Together, the four mutations made the engineered virus transmissible through the air, although it didn't kill the ferrets who caught it, or even make them very sick.
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