Sentence examples for mutation lowered the from inspiring English sources

Indeed, this single mutation lowered the methanol concentration for which the initial rates of alcoholysis and hydrolysis are equal from 2 M in CAL-A down to 0.3 M in its mutant, while the exceptional stability of the parental enzyme toward alcohol and temperature was conserved.

"Overall, the mutation lowered the risk of severe malaria by 88% in Tanzania, and 75% in Kenya," says molecular geneticist Maurine Hobbs of the University of Utah in Salt Lake City, a co-author of the study, which appears in the 9 November issue of The Lancet.

They found that each mutation lowered the activity of the hLCB1/hLCB2a heterodimer and was also able to generate varying levels of deoxy-SLs.

We found that (1) the V67L mutation lowers the global fluctuations in all modeled mini-inteins, stabilizing the mini-intein constructs; (2) the connecting linker length affects intein dynamics; and (3) the flexibilities of the linker and intein core are higher in the active structure.

As a consequence, invasion conditions for female-specific enhancing mutations are rendered more restrictive as the spread of the male mutation lowers the effective level of CI to (1−e)lCI (compare figure 5 where threshold values of −d rise with lower lCI).

The deleterious mutation lowers the expression of miR-16-1 and leads to CLL through the disruption of SRp20 binding site.

Therefore, we speculate that the P20R mutation lowers the solubility of the mutant αB-crystallin, causing protein self-aggregation and resulting in a more stable heteroaggregate with αA-crystallin.

This mutation lowers the energy level of the matrix state involved in substrate binding (Fig. 6) and thus the probability of being in that state would be much higher.

The loss of the stacking interactions in both of the translocation states makes it implausible that the decreases in both the forward and reverse translocation rates occur because the Y254V mutation lowers the free energy of the pre-translocation or post-translocation state energy wells.

Accordingly, most Gcd– mutations in eIF2Bβ and eIF2Bα affect buried residues (not shown in Figure 6) and are thus likely to affect the structure or stability of the protein, consistent with a loss-of-function mutation lowering the amount or activity of eIF2B.

Although we cannot rule out completely that the mutation lowers the intrinsic affinity of Mdm35 for Ups1, the results suggest that this loop, as in PITPs, could contribute to lipid exchange by closing access to the Ups1 cavity and sequestering PA.