Sentence examples for mutation loss of from inspiring English sources

These alterations occur by multiple mechanisms, including mutation, loss of heterozygosity (LOH) and promoter hypermethylation.

Possible mechanisms for inactivation of ABO include allelic loss (loss of heterozygosity LOH), mutation (loss of function) and silencing by DNA methylation.

Neither the 15F mutation (loss of tyrosine phosphorylation sites) in the SD nor the mPR mutation (disruption of the Src SH3-binding motif) in the SBD fully impaired the ability of p130Cas to promote cell migration.

Akt represents a nodal point in cell signaling and can be activated by several upstream events, including epidermal growth factor receptor amplification or mutation, loss of PTEN, and PIK3CA mutation.

Similar to rtel-1 mutation, loss of the condensin DPY-28 also results in additional COs.

TP53 mutation, loss of p16INK4A and overexpression of cyclin D1 are all associated with reduced survival.

In a study of lung cancers based on whole-genome sequencing, DACH1 emerged as a biologically significant target of mutation (loss-of-function alterations in particular) [ 35], and its homozygous deletion has been reported in some glioblastoma multiformes [ 36].

Gain of function mutations, loss of function mutations, and overexpression of GATA2 have been reported in acute myeloid leukemia.

To evaluate the efficiency of germ line transmission of the mutations, individual F0 fish carrying ezh1 mutations (loss of the BamHI restriction site) were outcrossed to wild-type TU to obtain F1 offspring.

In the context of these other mutations, loss of function of the activated oncoprotein may be selectively toxic [36].

Like cnn mutations, loss of these gene functions also affects the morphogenesis but not apical basal cell polarity.