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RUNX1 mutation localization seems to have no impact on CEBPA expression.
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Even for a particular isoform, its intracellular localization seems to vary during the cell cycle.
Thus, the function of actin patches rather than their polarized localization seems critical for polarized growth.
DA2 receptors main localization seems to be the postganglionic presynaptic nerve ending [ 22].
This sub-cellular localization seems to be a prerequisite to transformation.
These results indicate that the C-terminal mutation of the CD20 gene in this case caused abnormality of extracellular-antigen presentation, even though the protein expression and the cell membrane localization seemed to be normal.
However, the mutation of JMJ706 seems not to affect DNA methylation in tandem repeats (Sun 2009).
The biological nature of the P56S mutation seems complex.
A positive mutation status seemed correlated with further advanced stages.
If blocking the protein made by one mutated gene led to a second mutation -- as seemed likely -- what if that mutation could be identified and blocked?
These somatic DNA mutations known as driver mutations seem to be the prime cause in initiating tumorigenesis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com