Sentence examples for mutation loads in from inspiring English sources

Next, we determined the mutation loads in the 43 tissue samples of the index patient with the same Pyrosequencing® assay.

The m.8344A→G mutation loads in the blood of family members and in the tissue biopsy specimens were determined by a highly accurate Pyrosequencing® assay.

As the mutation loads in blood cells from the clinically unaffected relatives ranged from 0 93% (Figure 1A), we assume a critical threshold level for clinical manifestation in this family between 93 96% for the m.8344A→G mutation.

In search for a region-specific pathology in human individuals we determined the mtDNA/nDNA ratios along with the mutation loads in 43 different post mortem tissue samples of a 16-year-old female MERRF patient and in four previously healthy victims of motor vehicle accidents.

Nevertheless, some yield consistently smaller mutation loads in some range of mutation bias.

This difference highlights the importance of reproductive mode for the accumulation of mutation loads in the genome.

This may explain why wt littermates of mtDNA mutator mice may have a moderately increased mutation load in comparison with other wild-type mice whose mitochondria have never come in contact with the mtDNA mutator allele.

Quantification of total mtDNA mutation load in ageing tissues is difficult as mutational events are rare in a background of wild-type molecules, and detection of individual mutated molecules is beyond the sensitivity of most sequencing based techniques.

If the mutation load in the population is M, the probability of any locus being mutated will be M/10, and the probability of carrying two mutated alleles of any given gene will be (M/10 2 = M.10-8 and hence the effect on fertility would be (1- M.10-8)10,000 overall since the threat applies for every single one of the 10,000 essential genes.

Defining mutation load in individual pancreatic cancers and the optimal assay for patient selection may inform clinical trial design for immunotherapy in pancreatic cancer.

We found a significant decrease in mutation load in populations in which females exhibited a preference based on male age.