Sentence examples for mutation load reported from inspiring English sources

Exocyclic LPO- derived DNA-lesions are likely to contribute to the mutation load reported to occur in human tumors.

Such a high mutation load had not been reported before and had originally been considered incompatible with life because COX-activities were extremely low in cultured myotubes with homoplasmy for the mutation [8].

The few available studies on m.3243A > G carrier fetuses reported a uniform distribution of mutation load among different tissues from two heteroplasmic 24-and 25-week-old human fetuses [Cardaioli et al., 2000; Matthews et al., 1994].

In this study, we report for the first time a correlation between the urinary mutation load and cardiac involvement specifically, as evidenced by increased LVMI.

Here we report the results of an experiment designed to establish the relationship between starting mutation load and the subsequent change in fitness with MA.

A woman carrying the pathogenic mutation may thus have mutation-free embryos, advocating PGD as an appropriate procedure for preventing recurrence of affected offspring in carriers, at least in the mutant load range reported in this study.

For Medicago truncatula mutagenesis, it was previously reported that an EMS concentration at the point where germination begins to become compromised is optimal for obtaining a large mutation load while maintaining vigorous and fertile plants [ 20].

Previous studies reported a variety of ingeniously designed assay methodologies for the sensitive detection of JAK2 617F and MPL W515L/K mutations, with the analytical sensitivity around 1 5% mutation load [ 4, 16, 33– 33].

Absolute mutation load can range from zero (no load) to ten in our simulations.

This is because the mutation load is largely insensitive to the per-mutation fitness effect [18].

In addition, the effects of female preference on male gamete mutation load depended on mutation rate.