Sentence examples for mutation library demonstrated from inspiring English sources

In silico validation of the mutation library demonstrated high sensitivity for detecting resistance to RMP, with the majority of resistance mutations found in a single region of the rpoB gene [ 44].

The mutation frequency in fugu Mstn gene was similar to that identified in the medaka TILLING library, demonstrating that we were able to establish an effective protocol of the TILLING method in fugu.

The threshold calculations based on nuclear DNA control libraries demonstrated that the average proportion of mutations per base was 0.06 % and no base was mutated at greater than 0.8%% frequency (He et al. 2010).

Combining the mutation library with a rapid detection tool for whole sequencing data [ 34], we have demonstrated the potential for using next generation sequencing for detecting drug resistance.

These data indicate that the mutation library was successfully constructed.

Other mutants (G276K, G276Y, and G276N) at this site were also screened from the saturated mutation library and exhibited better catalytic properties compared to the wild type.

ENU induced mutation library was screened for a mutation in the fmr1 gene.

An insertional mutation library screen identified the CoATG26 gene as critical for pathogenicity.

We have compiled and released a mutation library for M. tuberculosis drug resistance [ 22].

hBChE libraries were made by introduction of mutations through PCR using doped oligonucleotides, subcloning PCR library fragments into the shuttle vector pENTR1A, transfer of the mutation library from pENTR1A to an adenoviral expression vector (pAD) through recombination, and then packaging of the mutation libraries in pAD in recombinant AD particles through transfection as described previously.

BRAF V600E mutation was demonstrated in 3.1% of colorectal carcinomas.