Sentence examples for mutation level was from inspiring English sources

Consequently, the mutation level was expressed as the percentage of fluorescent cells relative to the transfection efficiency.

Data from a recent clinical study support this hypothesis, showing that the BRAF V600 mutation level was significantly associated with a better response rate to vemurafenib during the first 10 months of treatment [ 14].

The mutation level is, therefore, a relative value and corresponds to the percentage of fluorescent cells.

For heteroplasmic mutations, interpreting the measured level of heteroplasmy is challenging, particularly if there is an intermediate level (20 80%), if the mutation is rare or unique to that particular family, or if the mutation level is known to change over time (as is the case for the most common pathogenic heteroplasmic mtDNA mutation, m.3243A>G) (Craven et al., 2011).

Similarly, a first generation transmittance of increased ESTR mutation levels was observed in mice exposed to cigarette smoke [34] and particulate air pollution [35].

A second comparison group for day 0 mutation levels was derived from a Phase I trial of KP1461 (Clay et al, manuscript in preparation) (Figure 3B, rightmost column), who, like the Phase IIa trial participants, had more advanced infection.

Using such quantitative measures, two mutation levels were apparent.

Although there was a low spontaneous background level of p53 mutation, this level was not increased by formaldehyde exposure, even at tumorigenic doses.

No mutation at genomic level was identified (data not shown).

The deleterious effect of this mutation at translational level was demonstrated by the observation that: 1) when it was associated with a null mutant allele, it produced absent or very reduced amounts of protein.

To explain the lack of correlation with tumor aggressiveness, we note that in this regime the mutation production level is high.