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This is a highly personal account of making decisions on basis of prenatal diagnostic information, specifically the identification of a mutation level of 68%.
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The JAK2 mutation levels of 24 selected samples (all of which had tested positive for the mutation using QuanTAS-PCR) were also tested with the commercial quantitative kit "JAK2 Muta Quant" (Ipsogen SA, Marseille, France).
Additionally, the type of auxotrophic mutations, level of supplementation required, and particular growth medium used all have large effects on yeast growth kinetics.
For the respective mutations' levels of penetrance (e in males and d in females) we chose values from the entire meaningful range.
In human glioma with IDH1/2 mutation, the level of D-2-HG accumulates as high as 5 35 mmol L−1 [63, 79, 80].
The purpose of this study was to identify the adenomatous polyposis coli (APC) tumor suppressor gene mutation and level of wild-type p53 protein expression in patients with oral submucous fibrosis (OSF).
Despite the potential for high viral mutation levels, the operation of purifying selection appears to effectively constrain lyssavirus evolution.
In half of the somatic mutations, the level of heteroplasmy was between 1 and 25%.
For some mutations, the level of heteroplasmy measured in blood is therefore unlikely to reflect the level in the ovary.
Combining the pdx1.3 mutation with mutations affecting the level of 'classical' quenchers of O2 (zeaxanthin, tocopherols) resulted in a highly photosensitive phenotype.
Obviously, sensitivity of the RAPD assay depends of the mutations level and it needs further investigations.
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