Sentence examples for mutation level is from inspiring English sources

The mutation level is, therefore, a relative value and corresponds to the percentage of fluorescent cells.

For heteroplasmic mutations, interpreting the measured level of heteroplasmy is challenging, particularly if there is an intermediate level (20 80%), if the mutation is rare or unique to that particular family, or if the mutation level is known to change over time (as is the case for the most common pathogenic heteroplasmic mtDNA mutation, m.3243A>G) (Craven et al., 2011).

Consequently, the mutation level was expressed as the percentage of fluorescent cells relative to the transfection efficiency.

Data from a recent clinical study support this hypothesis, showing that the BRAF V600 mutation level was significantly associated with a better response rate to vemurafenib during the first 10 months of treatment [ 14].

Similarly, a first generation transmittance of increased ESTR mutation levels was observed in mice exposed to cigarette smoke [34] and particulate air pollution [35].

A second comparison group for day 0 mutation levels was derived from a Phase I trial of KP1461 (Clay et al, manuscript in preparation) (Figure 3B, rightmost column), who, like the Phase IIa trial participants, had more advanced infection.

Using such quantitative measures, two mutation levels were apparent.

To explain the lack of correlation with tumor aggressiveness, we note that in this regime the mutation production level is high.

We would like to argue that mutational load, that is, decrease in fitness due to mutation, at individual level is much lower in mtDNA than in nuclear DNA.

Interestingly, the impact of F266A mutation on H3K4me3 level is modest in steady state conditions, but becomes quite striking with transcriptional shutoff of WDR5.

We compare variance measurements from human clinical data and from mouse models and show that the mutation level variance is clearly higher in the human data than it is in the mouse models at both the primary oocyte and offspring stages of inheritance.