Overall, the HX mutation leads more often to a gain than a loss of the Hox interaction potential.
It had long been known that the asymmetrical appearance of a creature was directly linked to the amount of mutation in its genome, so that more mutations led to more "fluctuating asymmetry".
The mutation led to a more than five-fold increase in maximum specific growth rate, from 0.0255 h−1 for S. cerevisiae TMB 3399 to 0.14 h−1 for S. cerevisiae TMB 3400, whereas P. stipitis grew at a maximum specific growth rate of 0.44 h−1.
Remarkably, in this issue of EMBO Molecular Medicine Zhou et al (2010) report a mutation (APP E682K) occurring in a case of early onset Alzheimer's disease, which disrupts this β′ cleavage and which, like the Swedish mutation, leads to more cleavage between residues 671 and 672 and thus more full-length Aβ.
For the npl3-120 strain, a decrease in transcript levels near the 3'end of the genes was observed (Figure 5 and Figures S2, S3 and S4), consistent with previous experiments showing that this mutation leads to more efficient termination [11].
Our results suggest that the S252W mutation leads to more severe palate dysmorphologies than the P253R mutation, confirming the pattern already described in patients with Apert syndrome (Slaney et al., 1996).
The results indicated that the GA 20-oxidase 1 (ga5) mutation leads to a more pronounced growth reduction in terms of SFW on the L er background compared with the Col background because differences between ga5 and L er were greater (29·7 % reduction compared with wild type) than those observed between ga20ox1-3 and Col (15·0 % reduction compared with wild type).
The reported de novo mutations lead to more flexibility and increased binding energy when compared to WT, recessive mutations lead to intermediate binding efficiency and polymorphic variants have no effect.
Taken together, these data show that in the RMY102 genetic background, the H4G94P mutation leads to growth defects more severe than, but distinct from, those caused by lack of Asf1.
This mutation leads to the usage of the more proximal PAS and to the expression of a transcript with a shortened 3′UTR and a potentially higher stability.
