It is noteworthy that the association of some top-ranked genes to syndromic deafness forms does not exclude them from being good NSHL candidates, as clearly demonstrated by USH1C involved both in Usher syndrome type 1C [36], and NSHL [37], [38], depending on which mutations it undergoes.
While the epitopes derived from sequentially conserved regions may undergo mutations, it is worthwhile to explore the structurally conserved regions as a new dimension for epitope prediction.
However, it underwent human adaptive mutations, which ultimately increased the person-to-person transmission [ 12].
For instance, the sex-determining region (SRY gene) of the Y chromosome may be transferred to an X chromosome, resulting in an XX normal male, or it may undergo mutation making it non-functional, resulting in an XY female.
He is aware that the mutations his work undergoes endow it with a sort of sedimentary thickness.
It also undergoes mutations in 60% of adult acute myeloid leukemia (AML) cases with normal karyotype.
The C4561S mutation undergoes aberrant thioester adduct formation; this may be because the C4561S mutation (also in a structurally important Cys-X-X-Cys Zn-binding motif) unfolds the protein and liberates Cys residues, which would otherwise be occupied as Zn ligands.
Between March 1982 and May 2005 the mutation carriers underwent a total of 1252 colonoscopies.
This experiment demonstrates that PIEZO1, carrying a human pathogenic mutation, can undergo transition from a pressure-gated mode to a voltage-gated mode provided that the inactivation gate is kept open.
To report a case of ex vivo oocyte retrieval from oophorectomized specimens in a BRCA1 mutation carrier undergoing surgical staging for ovarian cancer.
