Sentence examples for mutation it seems from inspiring English sources

In the absence of an EGFR-activating gene mutation, it seems likely that a functional EGFR pathway is necessary for EGFR TKIs to be effective.

Although it is possible that, in humans, sirenomelia is an autosomal-dominant genetic condition, with every single case caused by a new spontaneous mutation, it seems more likely that it has a combined genetic and environmental component.

Because of the complexity of the networks, the effect of mixing genomes through sexual reproduction and the chance of mutation, it seems unlikely that we will ever be able to predict the details of network output in an organism.

Although there are examples for which pathway activation and drug response can be predicted by a single oncogene mutation, it seems more likely that genomic analyses will be necessary to accurately predict response to molecular targeted agents (Lynch et al, 2004; Paez et al, 2004).

'Since I was writing about the transmission of a genetic mutation, it seemed to me sensible and also incumbent on me to reiterate the transition in terms of the literary form.

And given the distribution of the mutation, it seemed that the resistance wasn't just some complete fluke of nature.

In the case of analyzing pancreatic juice for p53 and K- ras2 mutations, it seems likely that only a small percentage of DNA harbors mutant DNA.

If one assumes that domestication involves a modest number of mutations, it seems reasonable to conclude that these mutations have had far reaching, though often relatively small, effects on multiple gene expression networks.

However, given that LRRK2 interactions with LRP6 (Fig.  6E), DVLs (21) and GSK3β (22) are all altered by pathogenic PARK8 mutations, it seems unlikely that β-catenin activation will remain unaffected.

Although several studies support that anti-EGFR monoclonal antibodies are not active in colorectal cancer patients with K- RAS gene mutations, it seems that K- RAS mutations have no predictive role in NSCLC patients treated with these agents (O'Byrne et al, 2009; Khambata-Ford et al, 2010), although limited data are available.

With the current available mutation data, it seems that CNVs in PINK1 are less common than simple loss-of-function mutations (see Supp. Table S4-2).