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The dut1Δ mutation is lethal in yeast, while a dut1-1 leaky mutant (point mutation) is viable [12], but sensitive to the presence of 5FU (50 µM) (our data).
elav null mutants are embryonic lethal, while the rbp9 null mutation is viable, but surprisingly confers a female sterility phenotype.
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The dutΔ (deletion) mutant is lethal in E. coli, but the dut-1 partial inactivation (point mutation) mutant is viable and sensitive to the presence of uracil (10 mM) or an analog of uracil, 5FU (50 µM) [11], [17].
Mice heterozygous for the Noc4l mutation were viable, fertile and exhibited no apparent abnormalities when observed over a long period of time.
Animals carrying this mutation are viable but present with growth retardation, polysyndactyly and tooth developmental abnormalities [13], [18].
Although the mcl1-101 mutation was viable in combination with a temperature sensitive allele of mis6+, mis6-302, the double mutant showed a decreased permissive temperature compared to each single mutant (Figure S1B).
Drosophila homozygous for this mutation are viable and fertile as previously observed for the Wwox mutants.
Mice homozygous for the H2afy mutation were viable, and survived to adulthood without discernible morphological abnormalities.
Mice that are homozygous for the targeted mutation are viable and fertile and do not display any gross behavioral abnormalities.
Mice that are heterozygous for the targeted mutation are viable and do not display any gross behavioral abnormalities.
Although females bearing this type of mutation are viable and appear to be normal, the development and survival of their embryos are compromised [ 9].
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