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Exact(34)
Since penetrance of the mutation is very high, those who have a mutated copy of the gene will have the disease.
Intuitively, this seems unlikely, but given the powerful selective advantage of being lactase persistent any mutation is very unlikely to be lost by genetic drift.
The detection of mutant DNA is critical for precision medicine, but low-frequency DNA mutation is very hard to be determined.
Conversely, imagine a mutation that's relatively soft, that's relatively dovish, this mutation is very good for the incumbents because the incumbents essentially beat up on it or score very highly on it.
Here the effectiveness of each defense mutation is very high (going from highly susceptible to the current virus population to highly resistant), and predator adaptation is delayed because a de novo mutation is necessary to counteract defense, thus meeting both criteria predicted by our analysis.
The mechanism of leaf-color mutation is very complicated.
Similar(25)
The P2RY8-CRLF2 fusion and CRLF2 F232C mutation were very rare (1/202 and 0/16 patients, respectively).
Overall the percentage of mutation was very similar (14% in FFPE tissue vs. 16% in fresh frozen tissue).
Muscle imaging findings in a patient with a R120G αBC mutation were very similar to those in desminopathy patients.
However, yeast expressing only the G94P mutation were very sick, whereas yeast expressing only the G94A mutation grew like WT cells.
In lung cancer, the average number of mutations is very high with more than 8.9 mutations/Mb (Network TCGAR, 2014) that is to say more than 10,000 mutations/genome.
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