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A germline mutation is usually inherited, and exists in all cell types of a body.
In genetic algorithms the operation of mutation is usually implemented as a change to a gene at a randomly selected locus in a chromosome.
This mutation is usually considered as a loss of function mutation in Human while it has been associated with an over stimulation of the IL-1β pathway in mouse [18].
In Mendelian disorders, the presence of a pathogenetic mutation is usually sufficient to manifest a phenotype.
For example, the evidence for a mutation is usually stronger at higher read depths [ 5].
Thus, this mutation is usually detected as a mixed population with wild-type [ 24].
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Drug-resistant bacteria like those with the NDM-1 mutation are usually a bigger threat in hospitals, where many patients are on broad-spectrum antibiotics that wipe out the normal bacteria that can hold antibiotic-resistant ones in check.
Male fetuses with the mutation are usually nonviable or die before 2 years of age.
In these latter tracts, we observed that one single nucleotide mutation was usually sufficient to replace one amino acid by the other (Additional file 2: Table S1).
112 Histologically, the great majority are of spindle cell phenotype, and almost all are positive for KIT immunohistochemistry. Nevertheless, KIT or PDGFRA mutation are usually absent in these GISTs.
First, the rates derived from mutation are usually calculated on a 'per generation' basis and are difficult to convert to actual time because the number of generations per year in natural populations or over evolutionary time scales is not known.
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