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Leucine has a similar hydrophobicity and therefore the mutation is unlikely to considerably destabilize the protein.
However this mutation is unlikely to have an effect on the NF-κB pathway as the other allele and possibly both β-TrCP2 alleles were wild type.
We concluded that β-catenin mutation is unlikely to contribute to tumorigenesis in SA.
This suggests that this mutation is unlikely to negatively affect the regulation of AR expression.
Our results, however, demonstrate that EGFR mutation is unlikely in cervical cancer.
Another recent in vivo study suggests that early formaldehyde-induced p53 mutation is unlikely to play a role in tumorigenesis.
Similar(41)
Conclusion: The present data indicate that polymorphism of the ERα gene and MDR3 gene 1712delT mutation are unlikely to play any significant role in obstetric cholestasis in affected Finnish women.
Conclusion: The present data indicate that polymorphism of the ERα and MDR3 genes 1712delT mutation are unlikely to play any significant role in obstetric cholestasis in affected Finnish women.
Consequently, this mutation was unlikely to result in sizable functional effects.
However, the TP53 mutation was unlikely to be acting alone: two other early mutations (PPP2R5B and FBX011) were detected, and have previously been reported to interact with TP53 to promote tumor growth.
However, the TP53 mutation was unlikely to be operating alone, since we also detected mutations in FBXO11 and PPP2R5B, which have been shown to interact with TP53 to drive tumor growth [ 49, 50].
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CEO of Professional Science Editing for Scientists @ prosciediting.com