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Exact(22)
An approximately optimal value of the fold increase α in mutation rate due to a mutator mutation is therefore given by αoptimal = kmut optimal/kmut.
The p.Leu77Arg but not p.Val101Met GCK mutation is therefore considered a pathogenic mutation associated with MODY.
The His170Ala mutation is therefore expected to modify the stability and charge of Asp187, altering in turn the spectral properties of the neighboring Trp347.
The heterozygous germline T294M mutation is therefore homozygous within the pancreas.
This mutation is therefore likely to be an immune escape variant.
The identified mutation is therefore likely to have a structural role and destabilize the protein fold.
Similar(38)
Except for exon 1, which encodes only 10 amino acids, the entire coding sequence was deleted and the mutation was therefore expected to be a null allele.
The slc127 mutation was therefore renamed arp9-127.
Disruption of the activity by this mutation was therefore causing other defects in the functionality.
Investigations into the consequences of a FARS2 mutation were therefore pursued.
The percentage of analyzed recurrent tumors bearing a mutation was therefore surprisingly low.
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