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Indeed, the probability that a gene containing an SSR is targeted by a nonsense mutation is several orders of magnitude higher than a gene without an SSR.
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The frequency of spontaneous and induced mitochondrial point mutations is several orders of magnitude lower than the incidence of petite mutants (Foury and Vanderstraeten 1992; O'Rourke et al. 2002).
These mutations are several orders of magnitude more frequent than in genes encoding other proteins [ 7- 11].
Because BRCA1 and BRCA2 mutations are several times more common in the Jewish than non-Jewish population, the analysis was repeated, but restricted to Jewish subjects (Table 2).
In one large Dutch family with a segregating BRCA1 mutation, there are several mutation carriers who have developed CRC.
"Although this test may help to identify people who have a previously undetected BRCA mutation, there are several limitations and the results may be confusing or misleading without appropriate education," said genetic counselor Erica Ramos, president of the society, in a statement.
However, in the present case, a pathogenic effect of this mutation is suggested by several data.
Because the assignment of genes to mutations is done based on co-occurrences, sometimes a mutation is assigned to several genes.
This is called selective mutation and there are several alternatives to identify this subset of mutation operators (Acree et al. 1979; Mathur 1991; Mresa and Bottaci 1999; Offutt et al. 1993).
Not all FOP cases are caused by the common mutation, as there are several FOP variants with varying phenotypes.
In Central-Southern Italy the prevalence of p.C282Y mutation is low and in several patients the disease has different causes.
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