Sentence examples for mutation is sensitive from inspiring English sources

The ALKF1174L mutation is sensitive to the ALK inhibitor crizotinib only at high doses and mediates acquired resistance to crizotinib in ALK-translocated cancers.

Selection of an inhibitor for which the historical mutation is sensitive would be recommended to reduce the risk of resistance to subsequent TKIs.

Although the physiological role of SuhB is not well understood, a suhB mutation is sensitive to cold, suggesting a potential role in cold-tolerance (Matsuhisa et al. 1995; Chen and Roberts 2000).

The role for H3K36 modification in coordinating DSB repair was further confirmed by the observation that H3K36R mutation was sensitive to bleomycin and IR.

However lysine 37 mutations in histone H2B did not alter cellular growth compared to an isogenic wild-type parent on media containing 0.05% MMS (data not shown) or 100 mM HU (Figure 4A), where cells bearing a H2B K123R mutation were sensitive to both.

A myeloid cell line with the KIT (M541L) mutation was sensitive to imatinib in preclinical studies [ 21, 22].

Interestingly, although the B7 mutation in TSA1 confers resistance to CHP, Timmermann et al. also show that cells harboring this mutation are sensitive to hydrogen peroxide.

H3.3 histones have been shown to be deposited in UVC-damaged regions to restore transcription (Adam et al. 2013), and chicken bursal lymphoma DT40 cells either depleted for histone H3.3 or harboring H3.3 with G34R/V mutation are sensitive to UV (Frey et al. 2014).

Most interestingly, the D842Y-mutation is sensitive to treatment with Gleevec.

It should be noted that malignant hyperthermia, a disease associated with RyR1 mutations, is sensitive to potassium chloride (Moulds and Denborough, 1974), and therefore a testing method in patients or biopsy samples need to be initiated prior to potassium supplementation.

Finally, the channel with E701C/E730C double mutations is sensitive to oxidation/reduction (redox) while the channels with single mutation (E701C or E730C) are not, arguing that the two introduced cysteine residues may form a disulfide bond and that E701 and E730 are thus solvent accessible and close to each other.