Sentence examples for mutation is retained from inspiring English sources

"There may be other factors in the tissue that determine whether the mutation is retained" and whether it triggers a malignancy.

More than 95% of the misfolded protein encoded by the F508del-CFTR mutation is retained in the ER and subsequently degraded by the proteasome [16]; consequently, less CFTR reaches the apical membrane and ion transport is impaired.

Recently chondrosarcoma has been found to harbor IDH1 and IDH2 mutations (5 15) and we published that the mutation is retained in a subset of chondrosarcoma cell lines [ 15].

4 Indeed, what seems most likely is that AR sensitivity through a number of mechanisms, including overexpression, coactivator upregulation, gene amplification or AR mutation is retained in a significant proportion of cases of mCRPC, with stimulation and growth occurring at low levels of circulating androgens.

The introduced mutation was retained, and thus rNiV(W−) was not reverted in the infected animals.

Although V179F is an uncommon mutation that occurs at a highly polymorphic position, this mutation was retained because of its frequent selection by etravirine and its profound effect on etravirine susceptibility when it occurs in combination with Y181C/I/V [15].

To verify that the VPg mutation was retained after transfection and passaging of the mutant S1-VPgR1 virus, HeLa cell monolayers were infected at an MOI of 25 for 5.5 hours and total cellular RNA was extracted using TRI Reagent Molecular Research Center , Inc).

In the metachronous metastasis, only the K-RAS mutation was retained.

The germline mutation was retained and the wild-type allele was lost, thus both copies were affected.

A single animal was isolated from each plate and maintained at the restrictive temperature (20°) to ensure that the suppressor mutation was retained.

We found that the poor reactivity of the N36C mutation was retained when combined with the improved N-terminal sequence (ESI, † Fig. S7 S9).