Sentence examples for mutation is prognostic from inspiring English sources

13– 19 Several older studies suggest that KRAS mutation is prognostic in CRC patients.

The test for interaction between BRAF mutation status and tumor site was not significant, hence we conclude that BRAF mutation is prognostic for SAR in all MSS patients.

BRAF mutation is prognostic for poorer OS (median OS mutation vs. wild-type, 8.6 vs. 20.8 months; P = 0.001; Fig. 3C).

In the global population, the BRAF mutation is prognostic for poorer overall survival and survival after relapse, while KRAS mutation is not prognostic for any of the three endpoints (Table  1).

The BRAF mutation was prognostic for overall survival in MSS and/or left-sided tumors subpopulations.

PI3- kinase mutations are prognostic for survival in independent datasets.

Some investigators claim that EGFR mutations are prognostic rather than predictive, because subset analysis of TRIBUTE or INTACT trials (comparing platinum chemotherapy with chemotherapy plus EGFR-TKI) indicated that patients with lung cancer having EGFR mutations did better even in patients treated only with chemotherapy (Bell et al, 2005; Eberhard et al, 2005).

There are inconclusive results on whether K-Ras mutation is a prognostic or predictive factor of advanced NSCLC treated with chemotherapy [27].

As this association was highly significant for patients receiving oxaliplatin, irinotecan or both, as well as for patients receiving bevacizumab or not, the conservative interpretation is that BRAF mutation is a prognostic rather than a predictive marker.

In other MSS-subpopulations involving left-sided tumors BRAF mutation is also prognostic (see Additional file 1).

The poorer PFS with first-line therapy suggests that BRAF mutation could be prognostic, predictive or both.