Sentence examples for mutation is primarily from inspiring English sources

A proportion (20 30%) of lung cancer patients with EGFR mutation is primarily resistant to EGFR TKIs.

Crossing with A. halleri and transgenic data have shown that an SCR mutation is primarily responsible for self-compatibility according to this prediction.

The SBDS proinvolved in RNA metabolism and ribosome-associated functions, but SBDS mutation is primarily linked to a defect in polymorphonuclear leukocytes unable to orient correctly in a spatial gradient of chemoattractants.

However in our analysis, the N163H/K/T mutation was primarily observed in isolates with reduced zanamivir sensitivity, which seems to indicate an opposite effect of mutation involving N163.

Interestingly, the p. (Phe508del) mutation was primarily prevalent among patients living in Gaza (68%) as compared to patients in the West Bank (32%).

Although more than half the variants described are single amino acid substitutions that may lead to the translation of mutated protein with altered function, there is reasonable expectation that the functional effects of heterozygous mutation are primarily due to haplo-insufficiency (Table I).

The contribution of the non-hydrophobic residues needs further analysis as it is unclear whether the effect observed from the double/triple non-hydrophobic-residue to alanine mutations is primarily due to an increase in overall hydrophobicity or to the loss of the specific polar side-chains.

We speculate that the differing average severity associated with these two mutations is primarily due to their contrasting abundance.

Often, the pathogenicity of rare mutations is primarily assessed through multiple reports of occurrence in diseased patients that are documented and routinely updated in mutation databases.

The end result of acquired mutations is primarily thought to be the formation of a stable activated form of the Kit homodimer due to mutations in exon 17 or, less commonly, a change in the 3-D conformation of the homodimer preventing imatinib binding and activity due to a mutation in exon 14 [87].

These studies raise questions as to whether familial AD driven by presenilin and APP mutations is primarily a result of aberrant Aβ expression, or if it is in fact a result of altered APP cleavage, and the resultant effects of altered APP cleavage on sAPPα, sAPPβ, Aβ, AICD, p3 and full-length APP.