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A loss of p53 function resulting from mutation is prevalent in human cancers.
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Our follow-up analysis revealed that the G1613A mutation was prevalent in patients who would later develop HCC.
PIK3CA mutation was prevalent in relapsed ER-positive disease (48%) and was associated with persistent ER positivity and a late relapse pattern.
These two mutations are prevalent in non-small cell lung cancer (NSCLC) and located within exons 18 21 in the vicinity of the ATP-binding site (Fig. 6a).
Epigenetic mutations are prevalent in MPNs but their interplay with aberrant JAK-STAT signaling is not known.
APC mutations are prevalent in CIN-CRC [3], but the Wnt pathway gene mutation spectrum in MSI-CRC is less well characterized, with mutations in the Axin homolog AXIN2 and the TCF-family transcription factor TCF7L2 identified in ∼25% and ∼35% of MSI-CRC, respectively [8], [9].
FLT3-ITD mutations are prevalent mutations in acute myeloid leukaemia (AML).
This is particularly obvious in certain geographic regions where these founder mutations are prevalent.
KRAS mutations are prevalent in other tumor types such as colorectal and pancreatic adenocarcinomas.
CDKN2A/ N2B and NOTCH1 mutations are prevalent in T-ALL, but not universal.
These virulence-attenuating mutations are prevalent in serogroup 1/2 but have not been observed in serotype 4b isolates (40 ).
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