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Detailed sequence analysis of codon usage at this site by H5 revealed that although this mutation is possible, currently circulating H5N1 viruses are not poised to acquire this amino acid change easily.
Allowing for more than one T C mutation is possible but would reduce the fraction of unambiguously alignable reads.
The fixation of even a deleterious mutation is possible if the population undergoes an extreme bottleneck [ 5].
With the introduction of high throughput TILLING technology ([ 15]), detection of even rare recessive mutation is possible [ 16, 17].
The statement in the abstract that a spontaneous mutation is possible owing to parental consanguinity does not make sense and should be deleted.
The closer C is to 1, the closer the graph is to a maximal clique, the set being so locked only one mutation is possible without lethality.
Similar(53)
Screening for germline p53 mutation was possible in 268 index cases among individuals fulfilling selection criteria.
Of the 309 eligible cases from whom material was received, successful analysis for aCGH, MGMT methylation and IDH1/2 mutation was possible in 267, 281 and 282 cases respectively; successful analysis for all parts of the study was possible in 236 (53% of randomised patients).
However, whether correction of HERG nonsense mutations is possible is unknown.
We have designed a genotyping assay based on polymerase chain reaction and DNA-Chip for HBV Starting from a unique specimen, analysis of polymorphisms at 150 positions along the genome and 383 mutations is possible as well as the determination of the genotype.
Taken together, these cases show that heterozygous loss-of-function mutations in SF-1 (NR5A1) can be found in children with severe forms of hypospadias and that male sex of rearing of children with SF-1 mutations is possible, but SF-1 mutations are not found frequently in association with minor forms of hypospadias.
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