Sentence examples for mutation is particularly from inspiring English sources

Accurate identification of point mutation is particularly imperative in the field of biomedical research and clinical diagnosis.

We have recently observed that this mucA mutation is particularly accentuated in Mismatch Repair System (MRS -deficient cells grown in vitro.

The variable efficacy of Na+ channel blockers in infants with the R1623Q mutation is particularly important in view of the fact that cellular biophysical and pharmacological studies showed effective restoration of channel function of this mutation by lidocaine[29].

The fact that binding sites for Grb2 and ShcA (and the close Grb2 relative Grap2) are closely associated with EGFR mutation is particularly intriguing, as increased binding of these SH2 domains would be strongly predicted to lead to activation of the RAS signaling pathway via recruitment of the RAS activator Sos [32], [33].

This C-terminal mutation is particularly interesting because the proximal regulatory domain important for CTM of Cav1.4 is still present in R1827X channels.

The second mutation is particularly interesting because it affects an Armadillo-like helical domain of the protein critical for its spatial conformation [ 47].

Furthermore, the incidence of K-RAS mutation was particularly low (6.1%).

The poor relative survival for carriers of an NBS1 mutation was particularly apparent in the first 5 years after diagnosis (HR=2.08; P=0.002).

On the other hand, the prevalence of BRCA1 mutation was particularly high in African-American patients diagnosed before age 35 years (16.7%), compared with young Hispanics (8.9%), non-white Hispanics without Ashkenazi Jewish ancestry (7.2%), and Asian-Americans (2.4%) [ 35].

The identification of point mutations is particularly essential in the fields of medical diagnosis and prognosis of many pathogenic and genetic diseases.

When deleterious mutations were particularly lethal for a cell, the fitness differential between deleteriously mutated and nondeleteriously mutated cells was marked.