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The new mutation is only found in one (large) class of dangerous bacteria and it only confers resistance to one particular antibiotic.
Fewer than half of the cases (46.3%) carry a missense or nonsense de novo variant and the overall rate of mutation is only modestly higher than the expected rate.
"But what if that particular mutation is only present in some of the metastases of the patient?" Only the metastases comprised of cells with mutation X would respond to treatment and shrink or go extinct; those without mutation X would continue to grow.
Mutation is only applied with a certain small mutation probability (P_{mutate}).
Generally, mutation is only detected in natural populations with a high number of individuals, after many generations.
And, to negate any blonde stereotypes, the mutation is only skin deep.
Similar(42)
T7EN1 cleavage assay and Sanger sequencing were performed, and p53 gene mutation was only detected in the mESCs but not in the MEFs (Fig. 1G).
The zanamivir-related Q136K mutation was only found here (Table 4).
Each mutation was only found in affected individuals.
A KRAS codon 61 mutation was only found in the Leeds cohort, whereas a BRAF mutation was only found in the Yokohama cohort.
Also, lambs homozygous for the c.960delG mutation were only produced the second year.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com