Sentence examples for mutation is modest from inspiring English sources
We note that the tenfold transition-state effect of the Y1043F mutation is modest and thus it could also be consistent with a third possibility that the OH group of Y1043 plays an indirect role in catalysis and forms an important hydrogen-bonding network in the active site rather than participates in proton transfer directly.
In the context of the full-length hexameric Rev-RRE complex, the effect of the Gln51Ala mutation was modest but reproducible, showing a twofold reduction in affinity in gel shift assays using a vast excess of protein over RNA and reduced accumulation of dimer species in assays with stoichiometric amounts of Rev and RRE.
Interestingly, the impact of F266A mutation on H3K4me3 level is modest in steady state conditions, but becomes quite striking with transcriptional shutoff of WDR5.
The above suggests that any preventive benefit of tamoxifen in women positive for the high risk BRCA1 mutation is likely to be modest, but that a larger benefit of the order of a 25 35% reduction in incidence may be conferred in BRCA2 mutation carriers.
Modern development is modest.
Household debt is modest.
He is modest and circumspect.
