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NELF-A is indeed vital as the NELF-A[KG] mutation is lethal over Df 3R e-R1, a deficiency that removes the locus, and this lethality is reverted by transposon excision.
Innovation in the natural world, in the form of mutation, is lethal, so species do it only when they are under dire stress, he said.
A ScPMA1 null mutation is lethal in haploid cells, suggesting that the protein is essential for yeast survival [14].
When homozygous, the deletion/replacement mutation is lethal in utero, with the embryos dying during the stage of yolk sac and early fetal liver erythropoiesis.
Finally, when present in homozygocity the mutation is lethal during gestation in both strains.
It is interesting to note that the HU mutation is lethal in Bacillus subtilis, which has no other histone-like protein [13].
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This property is important when screening SLs because within a maximal clique, at most one amino acid may mutate freely, any second mutation being lethal.
Furthermore, the slt2Δ mutation was lethal in myo1Δ suggesting that its expression was required for survival [ 6].
In Drosophila, Fusilli homozygous mutation was lethal, indicating that Esrp and Fusilli are both essential splicing factors despite substantial phylogenetic distance between mammals and flies.
Similarly, an unknown fraction of mutations is lethal and not ascertained as pathogenic.
The screen took advantage of the fact that a combination of sepF and ftsA null mutations is lethal (Ishikawa et al, 2006).
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