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Instead, a substitution of at least two nucleotides would be needed to generate the arginine-to-alanine mutation studied by Telezhkin43; thus, the R325A mutation is less likely to occur in vivo.
The role of the fourth mutation is less clear.
Hence, a synonymous mutation is less likely to affect protein function than a non-synonymous mutation.
However, familial amyotrophic lateral sclerosis (FALS) without superoxide dismutase-1 gene (SOD1) mutation is less heterogeneous than SALS.
APC mutation is less frequent in MSI-CRC than in CIN-CRC [10], [11], while activating mutations in CTNNB1, though widespread throughout the spectrum of human cancer, are rare in MSI-CRC [11].
Presumably, the selective disadvantage, caused by an active X-chromosome harboring a Bcor mutation, is less severe in some tissues leading to variable phenotypic effects in a mosaic fashion.
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Thymidine-analogue mutations and the K65R mutation were less common.
The 6 FALS patients without a SOD1 gene mutation were less homogeneous than the mutant SOD1 group, and notably did not overlap with this group, possibly because of alternative degenerative pathways.
The results obtained with CCC DNA revealed that in all five experiments the occurrence of the C2537T mutation was less than 85%, below the frequency ranging from 85 100% (average 93%) predicted by model 1 (Figure 1B).
The inhibitory effect of the P426A mutation was less severe than the S425D mutation.
There is no evidence in our clinical study that patients with the C61G mutation were less responsive to platinum than were patients with the more common 5382insC mutation.
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