Sentence examples for mutation is key from inspiring English sources

Thus, although not specific for AD, the P301L tau mutation is key to model tau neuropathology in transgenic animal models.

In particular, the relationship between mutation rate and the fitness effects of mutations is key.

Identification of somatic mutations is key to understanding the molecular mechanism of CRC and the development of novel therapeutics.

Furthermore, a clear understanding of epistasis among resistance mutations is key to predicting the spread of multidrug-resistant bacteria, as has been nicely demonstrated by Borrell et al.

The rate and effect of available beneficial mutations are key parameters in determining how a population adapts to a new environment.

The rate and fitness effects of mutations are key in understanding the evolution of every species.

For PI3K inhibitors, signaling through Erk in response to the HER3 ligand heregulin and HER3 abundance, but not phosphoinositide 3-kinase catalytic subunit alpha (PIK3CA) mutations, were key predictors of response.

Alteration or mutation of protooncogene is key factors in the development and progression of various types of tumours.

The p53 signalling pathway is central to regulating cell growth and death, and stabilisation of p53 by mutation is a key event occurring late in colorectal tumorigenesis (Baker et al, 1990).

The laboratory selection experiment found that L1014F mutation frequency, but not L1014S mutation, responded to deltamethrin selection, suggesting that the L1014F mutation is the key mutation conferring resistance to deltamethrin.

Based on the strong positive correlation between L1014F mutation frequency and mosquito survivorship in mosquito susceptibility bioassay and the evolutionary dynamics of L1014F mutation in response to deltamethrin selection, we suggest the L1014F mutation, not the L1014S mutation, is the key mutation associated with deltamethrin resistance.