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Exact(6)
In other words, the T22M mutation leads to selective depletion of the isoform 1, the only isoform in which this mutation is incorporated.
The desired mutation is incorporated at the 5' end of one or both internal oligonucleotides.
If a mutation is incorporated, the new coordinates of the C, N, H, O-atoms have to be updated in the PDB file.
Our observations bide very well for a next-generation vaccine in which the SapM mutation is incorporated in the improved BCGs (or attenuated M. tb strains).
This is comparable to the 3700-fold decrease in the kcat/ Km value for tyrosine when the identical mutation is incorporated into tyrosine hydroxylase.
Therefore, the classification of mutations as deleterious depends greatly upon the genetic background into which that mutation is incorporated, and fewer mutations have deleterious effects in genetic backgrounds with poor fitness [44].
Similar(54)
A 3 bp synonymous mutation was incorporated in rev at the site I in pCMVRdelta8.74 helper plasmid (Figure 4A), and the resulting helper plasmid was named pCMVRdelta8.74-sIM.
The mutation was incorporated into both the intact protein and PheH Δ117, a mutant PheH that lacks the regulatory domain.
The previously described Δ30 deletion mutation was incorporated into the p2 cDNA clone to form p2Δ30 [ 13].
The desired mutation was incorporated at the 5' end of one of the internal phosphorylated oligonucleotides (Table 1, oligonucleotide IR1).
So, this mutation was incorporated at sometime during the development of the JM101 strain from its parental strains JC3130, CSH51 and 71.18 [ 38, 39].
More suggestions(15)
evolution is incorporated
mutation is linked
mutation is labeled
mutation is parametrised
mutation is known
mutation is shown
mutation is implemented
mutation is located
mutation is considered
mutation is required
mutation is identified
mutation is inherited
mutation is presented
mutation is determined
mutation is done
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