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Among B lymphomas, the incidence of TP53 mutation is highest for chronic lymphocytic leukemia (CLL) (15%), Richter's syndrome (CLL complication, 40%), B high upgrade lymphomas (30%) and BL (40%).
BRCA1/2 testing is primarily proposed to women (index cases) in the family who developed BC as the probability of identifying a mutation is highest when testing starts with an affected woman.
As shown in Table 2, the frequency of the C9ORF72 mutation is highest in the FTD/ALS phenotype compared with the behavioural variant FTD and ALS phenotypes regardless of whether they are considered among all cases or familial cases only.
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The prevalence of KRAS mutation is higher than that in recent molecular studies [ 21, 24].
We find that EGFR is overexpressed and the risk of having BRCA1 mutation is higher in TNBC than non-TNBC.
Basal and induced expression of HIF-1α in FTC-133 cells bearing a PTEN mutation is high.
The risk of CBC among BC patients with a BRCA1/2 mutation is high, especially for younger patients.
For example, the K-ras gene mutation is higher in Caucasian NSCLC patients than in Asian NSCLC patients.
The salt wasting due to NCCT mutation is high enough to lower blood pressure and protect patients from hypertension.
At the stage of simple repeat, the rate of mutation is high and predominantly it is addition of repeat unit and hence size increases.
The recurrence risk is increased after the birth of two affected individuals, presumably because the proportion of germ cells that carry the mutation is higher.
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