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All that remains for natural selection to do is to check whether this mutation is "good" or "bad" in and of itself.
The prognosis in individuals with aHUS associated with only a CD46 mutation is good (0 6% risk of ESRD or death within 1 year of the first episode [ 12]).
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Usami, S. et al. Patients with CDH23 mutations and the 1555A>G mitochondrial mutation are good candidates for electric acoustic stimulation (EAS).
Smoking history and EGFR mutations are good predictors of response in patients treated with EGFR-TKIs.
Although EGFR mutations itself is not a predictor for a better survival in adenocarcinoma patients as shown in both the present study and a previous study (Kosaka et al, 2004), EGFR mutations were good predictor of the clinical benefit with patients with gefitinib treatment in such patients.
However, large deletions in Alu elements are rare and so the presence of the deletion in these elements, in addition to the four diagnostic mutations of AluYh3a1, is good enough evidence to consider this a unique subfamily, rather than due to parallel deletion.
Conversely, imagine a mutation that's relatively soft, that's relatively dovish, this mutation is very good for the incumbents because the incumbents essentially beat up on it or score very highly on it.
IDH1 mutation is a good prognostic biomarker given that patients with mutation had significantly longer PFS and OS than patients with wild-type IDH1 and suffered more likely from secondary GBMs.
Consequently we introduce motifbreakR, which allows the biologist to judge whether the sequence surrounding a polymorphism or mutation is a good match, and how much information is gained or lost in one allele of the polymorphism or mutation relative to the other.
The actions of p53 are influenced by other members of the p53 pathway and a straightforward 'normal is good – all mutation is bad' argument is unlikely to apply.
Median networks must assume that all haplotypes are identical by descent when, in fact, because of the high mutation rate of Y-STRs, there is good reason to believe that at least some could be identical by state.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com