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The former mutation is frequently associated with antifolate resistance.
P.Gly61Glu mutation is frequently present in PCG in Saudi Arabia and p.Glu229Lys is a novel one.
Particularly, researchers find that a single mutation is frequently enough to perturb one way.
As a consequence, G → T transversion mutation is frequently observed at the position of 8-oxoG modification.
A BRAF V600 E mutation is frequently associated with MLH1 promoter methylation in sporadic colorectal carcinomas (Koinuma et al, 2004).
The p53 mutation is frequently seen in pancreatic cancer, and its expression correlates with overall survival after pancreatectomy [ 18].
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This mutation was frequently associated with a myopathy and with a wide spectrum of cardiomyopathies.
However, the BCP mutation was frequently found in conjunction with the G1613A mutation or the C1653T mutation.
Consistent with previous reports, in our study, BRAF mutation was frequently observed in serrated adenomas (5 out of 8, 63%).
K-ras mutation was frequently detected in tubulovillous adenomas (24 out of 40, 60%), while BRAF mutation was mostly observed in serrated adenomas (5 out of 8, 63%).
The BRAF mutation was frequently observed in serrated adenomas and has been shown to be significantly correlated with the recently proposed serrated polyp-microsatellite instability pathway (Kambara et al, 2004).
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