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Therefore, the effect of the single mutation is felt globally, rather than locally in the active site, imparting to the protein an overall increase in the thermostability.
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However, this particular mutation was felt to be a false positive result, and further investigations identified a more likely mutation candidate (MLL2).
However, since this is a tightly packed part of the protein structure with the hydroxyl group being a part of an interaction network, mutation of the hydroxyl is felt at the backbone carbonyl by the toxin.
Alternatively, the recent common ancestry of all cattle isolates may have resulted in lack of analytical power, due to insufficient time for new variants to arise and for the effects of small selection coefficients associated with slightly deleterious or advantageous mutations to be felt.
Visual mutation is a habit with Sokurov.
The chance of a mutation is unknown.
The mutation is then moved higher on the list, as well as future mutations of the mutation, until the spammer is reduced to sending gobbledygook.
Whether such a mutation is likely anytime soon is unknown.
To me, mutation is the answer to everything.
The IDH-2 mutation is just one of many enzyme mutations that are found in acute myelogenous leukemia.
Generally, one mutation is not enough to cause cancer; the disease does not develop until other mutations occur.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com