Sentence examples for mutation is extremely from inspiring English sources

As a first result, we confirmed the strong association of IDH mutations with the tumor genomic profile [ 10]: virtually all 1p19q codeleted tumors are IDH mutated [ 17, 18] whereas IDH mutation is extremely rare in gliomas with EGFR amplification.

EGFR mutations in SCLC mostly manifest as a "transformation" after EGFR-TKI therapy in EGFR-mutated adenocarcinoma [ 8], whereas primary SCLC with EGFR mutation is extremely rare.

Yet, because the disease is extremely rare, the number of couples that both carry a genetic mutation is extremely rare too.

This type of Kras mutation is extremely rare in human tumors, especially lung cancer.

However, this mutation is extremely rare and has not been found in any other pedigree.

The rate of spontaneous mutation is extremely low, 10-8 10-9 mutations/site/year in eukaryotic genomes.

While further confirmation in additional cases of CCHS would be useful, such pathological specimens in confirmed cases of neonatal CCHS with PHOX2B mutation are extremely rare.

The data were even more significant for those with a G12C mutation (P=0.04 and P=0.006 for OS and DFS, respectively), but the number of patients with a G12C mutation was extremely small (n=6).

Crossing between mouse strains harboring various FGFRs mutations is extremely important to elucidate the interactions between different FGFRs.

This and many other examples (including those described in the paper) suggest that the problem of dominant mutations is extremely complex.

In the absence of functional studies illustrating the genotype phenotype relationship, validating such private mutations is extremely difficult because of the difficulty of conducting sufficiently powered association studies.