Sentence examples for mutation is expressed from inspiring English sources

An example of the latter is shown in Fig. 3, where a human Tau construct containing the FTDP-17-associated V337 M mutation is expressed in all 302 worm neurons via a pan-neuronal C. elegans promoter.

Since this is a knock-in mouse model, each mutation is expressed under the endogenous promoter, and therefore phenotypic differences were not due to differences in insertion sites or differential expression levels.

The genetic background in which a disease-associated mutation is expressed can have a profound impact on the resulting disease phenotype.

The suggestion that neurons in Plp1tgs are metabolically abnormal may be paradoxical considering that the mutation is expressed in Olgs and not in neurons.

The P193A mutation is expressed only in the N-terminally extended ADAR1p150 isoform and increases the effect of other AGS mutations in the same protein.

For this reason, it may be argued that a decrease in lifespan may be found when dj-1β mutation is expressed in a long-lived background (e.g. OR).

It is therefore of particular interest that apoE−/− mice fed the same percentage cholesterol as the HC diet used in our study had reduced plaque development when the apoE−/− mutation was expressed in a mouse strain that completely lacks expression of arginase II [34].

Full-length human Ran containing the Q69L mutation was expressed from a pPROEx vector as an N-terminally His-tagged protein containing a TEV protease site.

When variants of IN-V5 carrying each mutation were expressed in 293T cells, levels of the Y15A-V5, K186Q-V5 and LL241,242AA-V5 IN variants were significantly lower than that of WT (Figure S1A).

This finding is also supported by a recent publication showing unaltered learning abilities in very young (3 4 months) NEP-deficient mice [12], while it was significantly impaired if human Aβ (containing the Swedish double mutation) was expressed in addition in these knockout mice [13], [31].

This has not been previously reported; even in studies in which the identical knock-in mutation was expressed in all tissues, prostates were found to be normal.