Sentence examples for mutation is even from inspiring English sources

Moreover, the R306C mutation is even more detrimental than lacking the entire basic cluster.

The effect of the D108N mutation is even more drastic, resulting in a 150-fold decrease in kcat and a modest decrease (4-fold) in KM, consistent with a significant role of this residue in catalysis.

If the tumour is ER-negative but not TN, however, the probability of carrying a BRCA1 mutation is even less relative to when the tumour is ER-negative but of unknown TN status.

When excluding 1p19q codeleted tumors (considered as the hallmark of oligodendrogliomas), TP53 mutation was even more strongly correlated with IDH mutation: 57/98 (58.2%) of IDH mutated tumors was also mutated on TP53, versus 46/175 (26.2%, P < 0.0001) in nonmutated gliomas.

The effect of the nuc mutation was even more pronounced in biofilms initiated with higher inoculums, resulting in a doubling in thickness from approximately 10 µm to approximately 20 µm (Fig. S1).

The salmon module, which contained genes downregulated in cells carrying the TS mutation, was even more enriched for ID susceptibility genes, containing 18 genes known to cause ID (OR = 3.3, P = 3e-05).

Double and triple mutations are even more effective.

The SMC1 suppressor mutations are even more proximal to the Smc3 ATPase active site than smc3-D1189H.

R andom mutations were even less often predicted to have strong effect (~7%, Fig. 1B, dashed blue line).

A significant clinical heterogeneity, ranging from common chronic course to less frequent evolution to AML [13], [16] [18], exists among classical MPD patients with the JAK2 V617F mutation, and is even more diverse in patients with MDS/MPD overlap.

The superiority of Froh in detecting the homozygous mutation load is even more stark if one considers the unique effects of each estimate of F after controlling for their correlations with Froh.