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Her work on the effects of low-dose radiation on female germ-cells mutation in mammals indicated that only a fraction of mutation is due to low-dose environmental radiation.
The oxt6 mutation is due to the disruption of a complex gene (At1g30460) that encodes the Arabidopsis ortholog of the 30-kD subunit of the cleavage and polyadenylation specificity factor (CPSF30) as well as a larger, related 65-kD protein.
Thus, the dementia caused by the Arctic AβPP mutation is due to AD, albeit with unique features of AD neuropathology.
It is unlikely that the lethality resulting from this mutation is due to the lack of C-domain activity in terms of Ang II production.
The xprG2 loss-of-function mutation is due to the insertion of two base pairs which causes a frameshift mutation in the ninth codon of the xprG gene.
Nonhereditary somatic mutation is due to promoter hypermethylation of the MLH1 gene resulting in silencing of the gene causing similar MSI levels in the genome seen in 10% to 25% of sporadic tumors, especially colorectal and endometrial carcinomas [ 15].
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It is extremely unlikely that any of the sequence changes that we scored as a "true" mutation was due to a PCR amplification error.
In the duplicated (dp) mutant of I. nil, the mutation was due to the rearrangement of genomic structure by the Em/Spm transposable element [ 18].
The loss-of-function of CsGL3 in the mutation was due to the insertion of a 5005-bp activemous, active LTR-RT in the 4th exon of CsGL3.
To test if the suppression by the basic patch mutation was due to an inability of Dot1 to bind or methylate H3K79, we combined rsc2-V457M with either an H3 K79A mutation or dot1 null mutant.
Hence, the effects of the mutation are due to direct effects on the reactions of the enzyme and are informative of the role of this residue in those reactions.
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CEO of Professional Science Editing for Scientists @ prosciediting.com