The average distances per mutation are denoted in Table 1.
For ease of description, QML-AiNet using the modified mutation method will be denoted QML-AiNet MM) in this paper, while the one use the original mutation method is denoted QML-AiNet MM).
Presence of pseudogenized RAYT genes, containing nonsense or frameshift mutations or deletions, is denoted by italics.
The scaled product of the effective population size (N e ) and the mutation rate per locus per generation is denoted by θ = 4 N e μ.
For CT GAT → CT AAT, the first trinucleotide represents the first three nucleotides of the pentanucleotide and the mutation is CT G → CT A. Since the central nucleotide is a pyrimidine, the reverse complement is used and the mutation is stored as CAG → TAG and is denoted by CAG.1t (1t denotes that the first nucleotide has been mutated to a thymine).
Among all the relevant mutations (that is, all the mutations that give rise to resistant phenotypes) in the context of combination treatments, we will distinguish three types: Singly-resistant mutations, that is, mutations that confer resistance to only one drug (the number of mutations giving rise to resistance to drug s is denoted by the is count).
Using the same method, the temporary offspring of C2 is generated, which is denoted as T offspring 2. Step 5: Mutation Select a point on T offspring 1 randomly as a mutation point, which is denoted by M po int1.
We note that sfa is denoted in lowercase, because the dominance of characterized mutations was not established until after mutation identification.
A step size was given by (1/{text{N}}_{{rm parent}}), where ({text{N}}_{text{parent}} = 2cdot {text{N}}_{text{crossover}} + {text{N}}_{text{mutation}} = 2times 1 4+ 4= 3 2) and an initial position is denoted as ({text{Initial}}_{text{position}}), where (0< {text{Initial}}_{text{position}} < 1/{text{N}}_{{rm parent}}).
Concatenation is denoted by '+'.
