Sentence examples for mutation is deleterious from inspiring English sources

In SIFT (http://sift.bii.a-star.edu.sg/) the M158V mutation, as well as the known mutation R155H, was not tolerated (p = 0.00), meaning that the mutation is deleterious.

Purifying selection decreases the frequency of mutations that prove to be disadvantageous to carriers in a given environment, the magnitude of this decrease depending on the degree to which the mutation is deleterious.

Since the driver mutation is deleterious to a cell with only a few passenger mutations, there is a period of stasis in the number of cells until a clone of cells with enough passenger mutations emerges.

Thus, there is little doubt that the mutation is deleterious, causing STWS.

Functional data and cosegregation suggest that the c.5095C>T mutation is deleterious and predisposes carriers to family history of breast and/or ovarian cancer [ 46– 46].

If the mutation is advantageous (S IJ > 0), then q IJ > μ IJ, and if the mutation is deleterious (S IJ < 0), then q IJ < μ IJ.

Nor, the geneticists complained, had there been enough time for natural selection to do its work, given what they had discovered about the rate at which mutations occur, and the fact that most mutations are deleterious.

In the absence of Mad2p-dependent spindle checkpoint, both mutations are deleterious.

Let all mutations be deleterious.

A high mutation rate is usually associated with a fitness cost, because most mutations are deleterious.

Mutation and recombination probabilities are uniform across the genome, and all mutations are deleterious.