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Although there is progress regarding our knowledge on the cellular function of desmin within the cytoskeleton, the impact of each distinct mutation is currently not understood at all.
The mechanism underlying these in vivo consequences of the A66W mutation is currently unknown.
The worldwide prevalence of this mutation is currently unknown: as no carriers were identified in 96 female CKCS from the United Kingdom the defect may be present at a low level within the breed in this country.
Thus, Danusertib represents a promising new treatment option for patients suffering from IM-resistant CML and a phase II clinical trial, including CML patients in accelerated phase or blast crisis harboring the T315I mutation, is currently ongoing (NCT00335868, www.clinicaltrial.gov).
However, what constitutes the actual threshold for a defect caused by this mutation is currently unknown.
Understanding the neurobiology and clinical phenomenology of this novel mutation is currently a major research focus.
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Whether these previously unreported NPM-1 mutations will confer the same better outcome as previously reported mutations is currently unknown and warrants a larger study.
The detection of these mutations is currently performed by the reverse dot blot (RDB) hybridization technique, which could detect only known mutations.
The K70Q/Q151Mc set of mutations is currently rare among HIV-infected patients.
Interestingly, it has been reported that chicken DT40 B cells deficient for members of the FA pathway show a decrease in SHM [23], [26], although the precise mechanism for the decrease in the accumulation of non-templated mutations is currently unclear.
Based on these findings, repeated testing of RAS mutations is currently not recommended.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com