Sentence examples for mutation is considerably from inspiring English sources

We show that the number of abasic sites is significantly increased when the 3-methyladenine DNA glycosylase (Mag): AP endonuclease (Apn1) ratio is increased and that spontaneous frame shift mutation is considerably elevated when either Mag, or Mag plus Apn1, expression is elevated.

The frequencies of the c. 1080C>T and c.*543T>C variants were substantially higher in the Czech population whereas the frequency of the c. [833C; 844_845ins68] double mutation was considerably lower than in Africans.

Thus, the probability of transformants having no untargeted mutations is considerably increased both by using high-fidelity Taq polymerases and by minimizing the size of the PCR fragment.

It is interesting to note that the number of dominant mutations was considerably smaller in the primary tumour than the metastatic lesion.

PolZeta appears to be involved in the repair of at least some of these DSBs, as the frequency of HO-induced base substitution mutations was considerably lower in an isogenic rev3 Δ strain (Holbeck and Strathern 1997).

The fraction of immunogenic mutations, in contrast, is considerably higher.

The ASSA server is capable of analyzing these categories of mutations; however it is considerably slower than the Shannon pipeline (30 s per variant).

The Y516F mutation causes similar changes in the guanine nucleotide binding and transamidating activity characteristics of the protein as R580A, although the latter mutation is a considerably more potent mutation than the former.

Children and young adults with diabetes and a strong family history of diabetes: testing for HNF4A mutations Diabetes caused by mutations in the HNF4A gene is considerably less common (Table  1) than HNF1A mutations.

In the other cases, the identification of the causative mutation may be considerably more arduous.

As in the inbred lines, the latter two mutation types were considerably depleted in favor of synonymous SNPs compared with random expectation, as expected under purifying selection (44.1% missense mutations vs. 70.8% expected at random and 0.56% nonsense mutations vs. 4.4% expected at random, respectively, binomial test P < 1 × 10−300 in both cases).